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IAGIM - SOPs - Microbiological


DRUG DEVELOPMENT SOPs

" High Quality Cost Effective Drug Development & Manufacturing Excellence World Wide "... .

Archive of SOPs- MICROBIOLOGICAL

Pharmaceutical | Analytical | Microbiological | Stability

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SOP Control  
M-005-01-2008 Indexing procedure for Microbiology SOPs.  
M-010-01-2008 Index for Microbiology SOPs.  
  
Notebooks  
M-015-01-2008 Issue, use, and disposition of microbiological laboratory notebooks  
  
Samples and Sampling 
M-020-01-2008 The use of sterile sampling containers.  
M-025-01-2008 Representative sampling procedures.  
M-030-01-2008 Labeling of sample containers. 
M-035-01-2008 Receipt and logging of laboratory samples.  
M-040-01-2008 Storage of samples before and after testing.  
M-045-01-2008 Storing the Microbiology study samples under refrigerated conditions prior to analysis. 
M-050-01-2008 Number of samples required for performing microbiology tests.  
M-055-01-2008 Storage time limitations of samples prior to testing 
  
Bioburden of Starting Materials 
M-060-01-2008 Microbial testing of non active raw materials. 
M-065-01-2008 Total microbial Count specifications in Purified Water USP 
M-070-01-2008 Microbial testing in Container-Liner-Closure systems  
  
Media  
M-075-01-2008 Labeling and expiration dating of prepared media  
M-080-01-2008 Disposition of microbiological media and samples  
M-085-01-2008 Preparation, storage and use of microbiological media.  
  
Purified Water USP 
M-090-01-2008 Sampling sites and procedures for monitoring Purified Water USP  
M-095-01-2008 Total Microbial Count specifications in Purified Water USP  
M-100-02-2008 Microbial Limit Test specifications in Purified Water USP 
M-105-01-2008 Alert and Action limits on TMC in Purified Water USP 
M-110-01-2008 Frequency of microbial testing in Purified Water USP  
  
In-process Controls  
M-115-01-2008 Representative sample procedures on bulk products  
M-120-01-2008 In process control on bulk products 
M-125-01-2008 Time limitations on bulk product in process controls  
  
Finished Product Testing  
M-130-02-2008 Total microbial Count specifications in drug products.  
M-135-01-2008 Fungal Limit Test specifications in drug products.  
M-140-01-2008 Microbial Limit Test specifications in drug products.  
M-145-01-2008 Preservative efficacy testing and specifications in topical semi-solids 
M-150-01-2008 Microbial Assay testing in topical semi-solids  
  
Laboratory Housekeeping 
M-155-01-2008 Procedures for reduction of bioburden in the microbiological laboratory  
M-160-01-2008 The use and rotation of disinfectant swabbing solutions. 
M-165-01-2008 Prevention of contamination of media plates  
M-170-01-2008 Preparation, sterilization and storage of laboratory glassware and equipment  
  
Culture Control  
M-175-01-2008 Procedures for receipt, storage and handling of ATCC cultures  
M-180-01-2008 Handling Certificate of Analysis for ATCC cultures 
M-185-01-2008 Limitation on transfer procedures for ATCC cultures  
  
Test Method Control  
M-190-01-2008 Control and use of supplemental monographs in pharmacopoeial methods  
M-195-01-2008 The control of test methods #s and Edition #s in microbiology documentation.  
M-200-01-2008 Distribution of approved test method procedures 
M-205-01-2008 Validation of in-house test method procedures 
  
Formula Control 
M-210-01-2008 Recording and checking of method calculations  
M-215-01-2008 Procedures for rounding-off recorded numbers  
  
Investigation Reports 
M-220-01-2008 Procedures for handling abnormal or OOS results in a microbiology study. 
M-225-01-2008 Procedures for repeat testing  
M-230-01-2008 Investigation reports after repeat testing 
M-235-01-2008 Procedures for invalidating test results  
  
Aseptic Practice  
M-240-01-2008 Periodic monitoring of lamina flow units  
M-245-01-2008 Aseptic working practice and techniques for laminar flow units  
  
Environmental Monitoring  
M-250-01-2008 Bioburden mapping of laboratory environment  
M-255-01-2008 Bioburden mapping of manufacturing environment  
M-260-01-2008 Bioburden evaluation of manufacturing equipment 
M-265-01-2008 Bioburden sampling and evaluation of the environment air  
M-270-01-2008 The operation and use of Biotest Hycon air RCS sampler  
M-275-01-2008 Bioburden evaluation of personnel hands and clothing  
M-280-01-2008 Swabbing procedures for surface evaluation.  
  
Chart Control  
M-290-01-2008 Routine signing and checking of temperature charts  
M-295-01-2008 Review and control of temperature and humidity recording charts.  
  
Calibration , Validation and Qualification  
M-300-01-2008 Itemized list of microbiology laboratory equipment  
M-305-01-2008 Validation of laboratory autoclaves  
M-310-01-2008 Periodic revalidation of autoclaves and incubators.  
M-315-01-2008 Calibration schedule for microbiology laboratory instruments  
M-320-01-2008 Annual qualification program for laboratory instruments  
M-325-01-2008 Preventative maintenance programs for laboratory equipment 
M-330-01-2008 Reserved SOPs for specialized equipment and test methods  
  
Sanitation  
M-335-01-2008 Sanitation and housekeeping requirements of incubators. 
M-340-01-2008 Good House Keeping practice in a microbiological laboratory  
M-345-01-2008 Cleaning and sanitation procedures for incubators and refrigerators 
M-350-01-2008 Garmenting procedures for microbiological personnel  
  
Job Descriptions and Training  
M-355-01-2008 Using Microbiology SOPs and compliance program as a microbiology training tools.  
M-360-01-2008 The Do's and Don'ts of a microbiology study - as a department training tool. 
M-365-01-2008 Microbiology department compliance staff training  
M-370-01-2008 Job description of microbiology department personnel 
M-375-01-2008 Maintenance of microbiological personnel training records  
  
Contract Laboratories  
M-380-01-2008 Auditing procedures for a contract laboratory.  
M-385-01-2008 Mail/fax auditing procedures for a contract laboratory. 
  
Development SOP
 
M-390-01-2008 Microbiology development procedures for new products.  
  
Self-inspection and Auditing  
M-395-01-2008 Cross- referencing laboratory notebooks with computerized microbiology report sheets.  
M-400-01-2008 Auditing microbiology data in laboratory notebooks. 
M-405-01-2008 Self inspection procedures in a microbiology laboratory. 
  
Reviewing Documentation  
M-410-01-2008 Review and auditing microbiology documentation.  
M-415-01-2008 Reporting the test results of a microbiology study.  
  
Closing a Study  
M-420-01-2008 Accepting and signing-off a completed microbiology study.  
 
Available to IAGIM members via IAGIM Center - 24 SOPs and Validation Protocols
via IAGIM Online
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Download an Example SOP and Another One - Just to See

Pharmaceutical | Analytical | Microbiological | Stability


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