| |
KEY Rx DRUGS COMING OFF PATENT BY
DECEMBER 31, 2005 - DOP REPORTS
|
| Brand Drug |
Generic Name |
Patent Holder |
Indication |
1999 US Sales
(in millions) |
|
2000
|
| Vasotec |
Enalapril maleate |
Merck |
hypertension |
2,305.0 |
| Glucophage |
Metformin HCL |
BMS |
Type 2 diabetes |
1,317.0 |
| Humunlin |
Human insulin |
Eli Lilly |
diabetes |
1,087.5 |
| Neurontin |
Gabapentin |
Warner-Lambert |
epilepsy |
913.0 |
| Pepcid |
Famotidine |
Merck |
ulcers |
910.0 |
| Ceftin |
Cefuroxime axetil |
Glaxo Wellcome |
bacterial infections |
680.0 |
| BuSpar |
Buspirone HCL |
BMS |
anxiety disorders |
605.0 |
| Procardia XL |
Nifedipine |
Pfizer |
hypertension &
angina |
521.0 |
|
2001
|
| Prilosec |
Omeprazole |
AstraZeneca |
ulcers |
5,909.0 |
| Prozac |
Fluoxetine HCL |
Eli Lilly |
depression |
2,613.0 |
| Zestril |
Lisinopril |
AstraZeneca |
ulcers |
1,221.0 |
| Prinivil |
Lisinopril |
Merck |
hypertension |
815.0 |
| Accutane |
Isotretinoin |
Hoffman-LaRoche |
nodular acne |
705.0 |
| Mevacor |
Lovastatin |
Merck |
hypercholesterolemia |
600.0 |
|
2002
|
| Claritin |
Loratadine |
Schering-Plough |
allergic rhintis |
2,700.0 |
| Augmentin |
Amoxicillin &
clavulanate potassium |
SmithKline Beecham |
bacterial infections |
1,819.3 |
| Flovent |
Fluticasone proprionate |
Glaxo Wellcome |
asthma |
1,079.0 |
| Intron A |
Interferon alpha-2b,
recombinant |
Schering-Plough |
hairy cell leukemia,
Kaposi's sarcoma, hepatitis C & melanoma |
650.0 |
| Primaxin |
Imipemen &
cilastatin |
Merck |
bacterial infections |
575.0 |
|
2003
|
| Cipro |
Ciprofloxacin
HCL |
Bayer AG |
bacterial infections |
1,625.3 |
| Cardura |
Doxazosin mesylate |
Pfizer |
benign prostatic
hypertrophy |
794.0 |
| Flonase |
Fluticasone proprionate |
Glaxo Wellcome |
allergic rhinitis |
593.0 |
| Singulair |
Montelukast |
Merck |
asthma |
500.0 |
|
2004
|
| Procrit |
Epoetin alpha |
Johnson &
Johnson |
anemia |
1,505.0 |
| Taxol |
Paclitaxel |
BMS |
ovarian cancer,
Kaposi's sarcoma |
1,481.0 |
| Diflucan |
Fluconazole |
Pfizer |
vaginal &
esophageal cadidias |
1,002.0 |
| Lovenox |
Enoxaparin sodium |
Aventis SA |
deep vein thrombosis |
760.0 |
| Lupron |
Leuprolide acetate |
Tap Holdings |
prostate cancer |
730.0 |
| Paraplatin |
Carboplatin |
BMS |
ovarian cancer |
600.0 |
| Wellbutrin |
Buproprion HCL |
Glaxo Wellcome |
depression |
572.0 |
| Engerix-B |
Hepatitis B vaccine |
SmithKline Beecham |
Hepatitis B |
540.0 |
| Xenical |
Orlistat |
Hoffman-LaRoche |
obesity |
499.2 |
|
2005
|
| Zocor |
Simvastatin
|
Merck |
hyper cholesterolemia |
4,495.0 |
| Paxil |
Paroxetine HCL |
SmithKline Beecham |
depression |
2,109.2 |
| Zoloft |
Sertraline HCL |
Pfizer |
depression |
2,034.0 |
| Prevacid |
Lansoprazole |
Tap Holdings |
ulcers |
1,900.0 |
| Pravachol |
Pravastatin sodium |
BMS |
hyper cholesterolemia |
1,704.0 |
| Zithromax |
Azithromycin |
Pfizer |
bacterial infections |
1,333.0 |
| Combivir |
Lamivudine &
zidovudine |
Glaxo Wellcome |
HIV infections |
736.0 |
| Lamisil |
Terbinafine HCL |
Novartis |
tinea pedis |
700.7 |
| Zoladex |
Gosereline acetate
implan |
AstraZeneca |
endometriosis
& cancer pain |
686.0 |
| Zofran |
Ondansetron HCL |
Glaxo Wellcome |
nausea & vomiting |
674.0 |
| Aredia |
Pamidronate disodium |
Novartis |
hypercalcemia
& Paget's disease of the bone |
588.0 |
|
Source: FDA Orange Book, IMS Health, Int.J.of
Generic Drugs, Physicians' Desk Reference, Warburg Dillon Read,
Int.J.of Drug Development,
24 Volume Handbook of Drug Development.
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